The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.

@article{Karlin2014TheOS,
  title={The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.},
  author={Kristen L. Karlin and Gourish Mondal and Jessica K Hartman and Siddhartha Tyagi and Sarah J. Kurley and Chris S Bland and Tiffany Y-T. Hsu and Alexander Renwick and Justin E Fang and Ilenia Migliaccio and Celetta G Callaway and Amritha Nair and Rocio Dominguez-Vidana and Don X. Nguyen and Charles Osborne and Rachel Schiff and Li-yuan Yu-Lee and Sung Yun Jung and Dean P. Edwards and Susan G. Hilsenbeck and Jeffrey M. Rosen and Xiang H. F. Zhang and Chad A. Shaw and Fergus J. Couch and Thomas Westbrook},
  journal={Cell reports},
  year={2014},
  volume={9 4},
  pages={1318-32}
}
Defining the molecular networks that drive breast cancer has led to therapeutic interventions and improved patient survival. However, the aggressive triple-negative breast cancer subtype (TNBC) remains recalcitrant to targeted therapies because its molecular etiology is poorly defined. In this study, we used a forward genetic screen to discover an oncogenic network driving human TNBC. SCYL1, TEX14, and PLK1 ("STP axis") cooperatively trigger degradation of the REST tumor suppressor protein, a… CONTINUE READING
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