The oncogene c-Jun impedes somatic cell reprogramming


Oncogenic transcription factors are known to mediate the conversion of somatic cells to tumour or induced pluripotent stem cells (iPSCs). Here we report c-Jun as a barrier for iPSC formation. c-Jun is expressed by and required for the proliferation of mouse embryonic fibroblasts (MEFs), but not mouse embryonic stem cells (mESCs). Consistently, c-Jun is… (More)
DOI: 10.1038/ncb3193


9 Figures and Tables

Blog articles referencing this paper

Slides referencing similar topics