The oncofetal H19 RNA connection: hypoxia, p53 and cancer.

  title={The oncofetal H19 RNA connection: hypoxia, p53 and cancer.},
  author={Imad J. Matouk and Shaul Mezan and Aya Mizrahi and Patricia Ohana and Rasha Abu-lail and Yakov Fellig and Nathan Degroot and Eithan Galun and Abraham Hochberg},
  journal={Biochimica et biophysica acta},
  volume={1803 4},
Expression of the imprinted H19 gene is remarkably elevated in a large number of human cancers. Recently, we reported that H19 RNA is up-regulated in hypoxic stress and furthermore, it possesses oncogenic properties. However, the underlying mechanism(s) of these phenomena remain(s) unknown. Here we demonstrate a tight correlation between H19 RNA elevation by hypoxia and the status of the p53 tumor suppressor. Wild type p53 (p53(wt)) prevents the induction of H19 upon hypoxia, and upon its… CONTINUE READING

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