The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration.

@article{Lawson2014TheOR,
  title={The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration.},
  author={Campbell D Lawson and Keith Burridge},
  journal={Small GTPases},
  year={2014},
  volume={5},
  pages={e27958}
}
Rho GTPases play an essential role in regulating cell spreading, adhesion, and migration downstream of integrin engagement with the extracellular matrix. In this review, we focus on RhoA and Rac1--2 Rho GTPases that are required for efficient adhesion and migration--and describe how specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the extensive crosstalk that exists between them. In particular, we assess the role of GEFs and GAPs in light of… CONTINUE READING
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