The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility.

@article{Hawcroft2012TheOP,
  title={The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility.},
  author={Gillian Hawcroft and Mil{\`e}ne Volpato and Gemma Marston and Nicola Ingram and Sarah L Perry and Andrew J. Cockbain and Amanda D Race and Alessandra Munarini and Andrea Belluzzi and Paul M. Loadman and Patricia Louise Coletta and Mark A Hull},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 5},
  pages={1724-37}
}
BACKGROUND AND PURPOSE The omega-3 polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA) has antineoplastic activity at early stages of colorectal carcinogenesis, relevant to chemoprevention of colorectal cancer (CRC). We tested the hypothesis that EPA also has anti-CRC activity at later stages of colorectal carcinogenesis, relevant to treatment of metastatic CRC, via modulation of E-type PG synthesis. EXPERIMENTAL APPROACH A BALB/c mouse model, in which intrasplenic injection of… CONTINUE READING
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