The oligosaccharide α-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults

  title={The oligosaccharide $\alpha$-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults},
  author={Diana Gentilcore and Lora Vanis and Jasmine C. Teng and Judith M. Wishart and Jonathan David Buckley and Christopher K. Rayner and Michael Horowitz and Karen L Jones},
  journal={British Journal of Nutrition},
  pages={583 - 587}
In healthy older subjects, the glycaemic response to carbohydrate-containing meals is dependent on gastric emptying and intestinal absorption; when the latter is slowed, the magnitude of the rise in glucose is attenuated. The oligosaccharide α-cyclodextrin has been reported to diminish the glycaemic response to starch in young adults; this effect has been attributed to the inhibition of pancreatic amylase. We examined the effects of α-cyclodextrin on gastric emptying of, and the glycaemic and… 

Alpha-Cyclodextrin Attenuates the Glycemic and Insulinemic Impact of White Bread in Healthy Male Volunteers

Alpha-CD complies with the current definition of dietary fiber in every respect and reduces the areas under the curve of blood glucose and insulin significantly by 59% and 57%, respectively, demonstrating that alpha-CD inhibits and thereby delays starch digestion.

Synthesis of novel α-glucans with potential health benefits through controlled glucose release in the human gastrointestinal tract

The synthesis and digestion kinetics of novel α-glucans, including small oligosaccharides or larger polysaccharides based on glucose units linked in different positions by α-bonds, are reviewed.

Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia

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Positive postprandial glycaemic and appetite-related effects of wheat breads enriched with either α-cyclodextrin or hydroxytyrosol/α-cyclodextrin inclusion complex

Encorporation of encapsulated HT offered similar overall acceptability, due to the bitter taste-masking effect provided by α-CD, and a slightly additional positive effect in postprandial glycaemia and satiety and the development of foods with favorable metabolic effects is of great importance for the prevention of chronic diseases.

The Soluble Fiber α-Cyclodextrin Does Not Increase the Fecal Losses of Dietary Fat in Adults-A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial.

Great stool loss and lesser appearance in plasma TGs of tripalmitin- derived [14C] compared with triolein-derived [3H] TGs imply different metabolic handling of these 2 dietary fat tracers.

Cyclodextrins in Food Technology and Human Nutrition: Benefits and Limitations

Cyclodextrins are tasteless, odorless, nondigestible, noncaloric, noncariogenic saccharides, which reduce the digestion of carbohydrates and lipids, which make them bioactive food supplements and nutraceuticals.

Cyclodextrin in starchy foods

Cyclodextrins are widely used in various fields including food industry. In this review, their role in high carbohydrate-containing, starchy foods are reviewed and discussed. Both the effects as

The Effect of Alpha-Cyclodextrin on Postprandial Glucose Excursions: a Systematic Meta-Analysis

The meta-analysis presented here provides a review of studies conducted on the effect of CD on the rise of blood glucose levels after consumption of ~50 g of starch.

Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system.

It is shown that oral administration of α- CyD and dimethyl α-CyD suppresses sucrose-induced hyperglycemia in an in vivo evaluation system using silkworms and that the silkworm system is useful for evaluation of suppressive activities of α.Cyclodextrins derivatives against postprandial hyper glycemia.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to alpha-cyclodextrin and reduction of postprandial glycaemic responses (ID 2926, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

  • Biology
  • 2012
It is concluded that a cause and effect relationship has been established between the consumption of alpha-cyclodextrin with starch-containing meals and reduction of post-prandial glycaemic responses.



Dose-Dependent Inhibition of the Post-Prandial Glycaemic Response to a Standard Carbohydrate Meal following Incorporation of Alpha-Cyclodextrin

Background: This study evaluated the dose-response effects of α-cyclodextrin, a cyclic oligosaccharide, on the glycaemic and insulinaemic responses to the consumption of a standard carbohydrate meal.

Acetylation of or beta-cyclodextrin addition to potato beneficial effect on glucose metabolism and appetite sensations.

A minor modification insulinemic (1-2%) of native potato starch improved the glycemia, insulinemic, and satiating properties of a meal, especially true for the beta-cyclodextrin-enriched starch.

Fate of beta-cyclodextrin in the human intestine.

It is concluded that beta-cyclodextrin is poorly hydrolyzed in the human small intestine but that it is fermented by the colonic flora with apparent minimal H2 production.

Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient.

It is concluded that glucose sensors are present in both the proximal and the distal gut and the inhibition was related to the length of the small intestine exposed to glucose.

Gastric emptying in early noninsulin-dependent diabetes mellitus.

In patients with early NIDDM, gastric emptying of 75 g glucose is similar to that of normal subjects and is a significant determinant of the glycemic response.

Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.

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Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity.

Viscous types of dietary fibre are most likely to be therapeutically useful in modifying postprandial hyperglycaemia.

Altered Postprandial Insulin Requirement in IDDM Patients With Gastroparesis

The results suggest that IDDM patients with gastroparesis, accompanied by impaired solid and liquid emptying, have an altered postprandial insulin requirement.

Effect of variations in small intestinal glucose delivery on plasma glucose, insulin, and incretin hormones in healthy subjects and type 2 diabetes.

It is concluded that modest variations in the initial rate of duodenal glucose entry may have profound effects on subsequent glycemic, insulin, and incretin responses in both health and type 2 diabetes.

Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects

Results indicate in normal subjects that gastric emptying accounts for about 34 % of the variance in peak plasma glucose after a 75-g oral glucose load and plasma glucose levels at 120 min are inversely, rather than directly, related to gastric emptied.