The olfactory bulbectomy model in mice and rat: one story or two tails?

@article{Hendriksen2015TheOB,
  title={The olfactory bulbectomy model in mice and rat: one story or two tails?},
  author={Hendrikus Hendriksen and S Mechiel Korte and Berend Olivier and Ronald S. Oosting},
  journal={European journal of pharmacology},
  year={2015},
  volume={753},
  pages={105-13}
}
Olfactory bulbectomy (OBX), the surgical removal of the olfactory bulbs, lead, both in mice and rats, to a specific set of behavioral changes in social behavior, cognitive function and activity. The latter is often used as a readout measure to predict antidepressant effects of new compounds. More recently, the model is used to study neurodegeneration and the associated cognitive decline. Although most of the OBX-induced behavioral and neurochemical changes seen in mice and rats are very similar… CONTINUE READING

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