The olfactory bulbectomised rat as a model of depression

@article{Song2005TheOB,
  title={The olfactory bulbectomised rat as a model of depression},
  author={Cai Song and Brian E. Leonard},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2005},
  volume={29},
  pages={627-647}
}
  • Cai Song, B. Leonard
  • Published 31 December 2005
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
Bilateral olfactory bulbectomy results in changes in behavior, and in the endocrine, immune and neurotransmitter systems, that simulates many of those seen in patients with major depression. The olfactory system in the rat forms a part of the limbic region in which the amygdala and hippocampus contribute to the emotional and memory components of behavior. However, the loss of olfaction alone, which results from bulbectomy, is not the major factor that contributes to the behavioral abnormalities… Expand
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TLDR
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Abstract Removal of the main olfactory bulbs in rats has been shown to alter neuronal function in brain areas involved in emotional regulation and homeostasis. These neuronal alterations result inExpand
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Publisher Summary This chapter reviews the usefulness of the bulbectomy model and gives a detailed account of the neuroanatomical and behavioral effects of bilateral bulbectomy, followed by aExpand
Changes in neurotransmitter metabolism following olfactory bulbectomy in the rat
  • S. Jancsár, B. Leonard
  • Medicine, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
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TLDR
It is concluded that changes in neurotransmitter 'turnover' in these brain regions are attributable to the destruction of the olfactory bulbs and may contribute to the behavioural deficits which the authors, and others, have reported elsewhere. Expand
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TLDR
As many of the changes exhibited by the OB rat are qualitatively similar to those observed in depressed patients, it may be concluded that the OB rats are a model of depression and not just a means whereby putative antidepressants may be tested. Expand
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TLDR
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The results from studies in the olfactory bulbectomized (OB) rat model of depression clearly show that the changes in the immune system following bulbectomy are similar to those reported in depressedExpand
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TLDR
The present study confirms the apparent lack of activity of mianserin in two other tests (reserpine reversal and potentiation of noradrenaline) and shows that, in the relatively low doses used in the bulbectomy model, the established antidepressants may also fail to give positive responses in these other tests. Expand
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Data indicates a strong region-specific dysregulation of ALLO homeostasis in brains of OB rats which may contribute to the formation of the bulbectomy syndrome via a sustained reduction in physiological GABA-ergic tone in amygdala and frontal cortex. Expand
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The results suggest that IL-2 may have modulatory functions on behavioural, neurochemical, hormonal, and immunological aspects of the OB rat model of depression. Expand
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TLDR
It is proposed that normalization of allopregnanolone cerebrocortical levels may contribute to the antidepressant-like profile of these drugs in the olfactory-bulbectomized rat model of depression. Expand
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