The occurrence of tolerance to a central depressant effect of nicotine.

@article{Morrison1972TheOO,
  title={The occurrence of tolerance to a central depressant effect of nicotine.},
  author={Cathleen F. Morrison and Jane A. Stephenson},
  journal={British journal of pharmacology},
  year={1972},
  volume={46 1},
  pages={151-6}
}
1. Rats were injected with 0.8 mg nicotine/kg, 0.8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.2. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection. 

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