The occurrence of ochratoxin A in dust collected from a problem household

  title={The occurrence of ochratoxin A in dust collected from a problem household},
  author={John L. Richard and Ronald D. Plattner and Jeffrey L May and Sandra L. Liska},
Accumulated dust samples were collected from the heating ducts in a household where signs resembling ochratoxin poisoning in animals occurred. Several Penicillium spp. and Aspergillus ochraceous had been identified previously from air samples taken from this house. A composite sample from six collected samples was examined by HPLC, and it was determined that 58 ppb of ochratoxin A was present in this sample. A second set of six samples was collected and determinations were made by HPLC of the… 
Ochratoxin A in airborne dust and fungal conidia
The results show that airborne dust and fungal conidia can be sources of OTA, and peak exposures to airborne OTA may be significant, e.g., in agricultural environments.
Evidence of ochratoxin A conjugates in urine samples from infants and adults
En enzymatic hydrolysis of urine samples is highly advisable in order to avoid an underestimation of the OTA-exposure and to observe whether OTA phase-II-metabolites may escape detection when direct methods are applied for urinary biomarker analysis.
Characterization and validation of sampling and analytical methods for mycotoxins in workplace air.
Methods to monitor occupational exposure to seven of the most frequently occurring airborne mycotoxins have been characterized and validated, and it was observed that airborne particles may be more contaminated than the bulk material itself.
Black Aspergillus species: implications for ochratoxin A in Australian grapes and wine.
The ecology of ochratoxin A production by black Aspergillus spp.
Determination of ochratoxin A in foods: state-of-the-art and analytical challenges
Analytical methods for evaluation of the occurrence of OTA in foods, human exposure, and risk assessment are critically reviewed and synthetic counterparts to natural antibodies in the form of molecularly imprinted polymers seem a promising alternative to IAC for sample preparation.
A Study of the Toxicity of Moulds Isolated from Dwellings
An analysis of the toxicity of moulds isolated from 34 dwellings with mould-affected walls was performed. During the analysis 74 moulds strains were isolated, 17.5% of them were toxic. Detailed
Time and temperature dependent microbiological and mycotoxin (ochratoxin-A) levels in boza.
Mycotoxins and Mycotoxicoses, Detection and Analysis: A Review in Retrospect
Mycotoxins are recognized as toxic compounds of great concern in the context of human health and economy. Mycotoxins are toxic chemical products formed as secondary metabolites by some fungi that


Ochratoxin A as a contaminant in the human food chain: a Canadian perspective.
It is demonstrated that ochratoxin A is present in the blood of people in Canada and that two possible points of entry of this toxin into the human food chain are contaminated grain and pork products.
Ochratoxin A in human blood in European countries.
  • B. Hald
  • Medicine, Biology
    IARC scientific publications
  • 1991
The frequency of contamination of human sera seems to indicate continuous, widespread exposure of humans to ochratoxin A.
Ochratoxin A in dried vine fruit: method development and survey.
Ochratoxin A and aflatoxins were determined in 60 samples of retail dried vine fruits purchased in the United Kingdom using acidic methanolic extraction, immunoaffinity chromatography clean-up and HPLC determination.
Possible sources of ochratoxin A in human blood in Poland.
Individual daily intake of the mycotoxin, estimated on the basis of residues in human serum, was found to be 0.4 ng/g of food consumed.
Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy.
This is the first report which elucidates the association of ochratoxin A and citrinin and a naturally occurring disease in domestic animals.
Risk assessment of the mycotoxin ochratoxin A.
It is recommended that exposure to OA be kept to a minimum, and further monitoring programs are required to better define the overall residue profile of OA in cereal grains, animal feeds, animal food products, and human blood.
Human ochratoxicosis in France.
The prevalence of human ochratoxicosis in France is being determined using serum and plasma collected from apparently healthy people using high-performance liquid chromatography and spectrofluorimetry for detection and quantification.
Human exposure to ochratoxin A.
Over a nine-year period during screening campaigns in villages where Balkan nephropathy is endemic, human blood samples were collected and analysed for ochratoxin A and dried beans were found to be more frequently contaminated with the toxin.
Ochratoxin A, a Toxic Metabolite produced by Aspergillus ochraceus Wilh.
This species has also been frequently recovered in low counts from South African cereal and legume crops and has been reported as constituents of the mycoflora characteristic of ‘katsuobushi’ and other fermented fish preparations.
Experimental avian nephropathy. Changes of renal function and structure induced by ochratoxin A-contaminated feed.
One-day-old chickens were fed ochratoxin A-contaminated diets at 2 levels: 0.3 and 1 mg ochRatoxin A per kg feed, for 341 days, with changes in renal function characterized by impairment of glomerular and tubular function, indicated by a decreased inulin clearance, TmPAH and decreased urine concentrating capacity.