The occurrence of marker cells in fetal hematopoiesis of beige (Chédiak-Higashi) mouse.

@article{Yatabe1983TheOO,
  title={The occurrence of marker cells in fetal hematopoiesis of beige (Ch{\'e}diak-Higashi) mouse.},
  author={M Yatabe and Wataru Takahashi and Ototaka Higashi},
  journal={The Tohoku journal of experimental medicine},
  year={1983},
  volume={140 3},
  pages={
          331-4
        }
}
The presence of neutrophils and their precursors with peroxidase-positive and sudanophilic giant granules, which are characteristic of Chédiak-Higashi syndrome (CHS), in the fetal liver and blood of beige (CH), but not of the control C 57 Black, mice was observed. This finding supports the view that the prenatal diagnosis could be possible, if the fetal blood specimen is obtainable safely, assuming the occurrence of similar marker cells in fetal hematopoiesis in CHS of human. 
View on PubMed
jstage.jst.go.jp

References

SHOWING 1-10 OF 15 REFERENCES
Chediak-Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation.
TLDR
Bone marrow transplantation to mice with the Chediak-Higashi syndrome resulted in normal granulopoiesis and a reversal of their increased susceptibility to challenge with intravenous Candida albicans, suggesting that the leukocyte defect in CHS can be reversed by marrow transplantations.
Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice
TLDR
Primary embryonic fibroblasts isolated from beige (Chediak-Higashi) mice develop pathognomonic giant granules in vitro and are highly susceptible to shape changes induced by colchicine.
Chédiak and Higashi's disease: probable identity of a new leucocytal anomaly (Chédiak) and congenital gigantism of peroxidase granules (Higashi).
  • A. Sato
  • Medicine
    The Tohoku journal of experimental medicine
  • 1955
TLDR
Chediak and Higashi's Disease or Chediak-Higashi's Leuco-anomaly is suggested for this new clinical entity, which is considered as two different manifestations of one and the same clinical entity.
Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate.
TLDR
The association of elevated cAMP and impaired function in the polymorphonuclear leukocytes of patients with the Chediak-Higashi syndrome may be related to abnormal microtubular assembly.
Totipotent hematopoietic stem cells: Normal self-renewal and differentiation after transplantation between mouse fetuses
Prenatal diagnosis of hemoglobinopathies. A review of 15 cases.
TLDR
Although prenatal diagnosis of hemoglobinopathies is feasible, the present frequency of fetal loss and diagnostic error indicates need for improvement.
Prenatal genetic diagnosis. I.
Hereditary leukocyte anomalies - From a constitutional point of view
  • J. Pediat. Practice (Shonika-shinryo),
  • 1982
Reversal of natural killer defect in a patient with Chédiak-Higashi syndrome after bone-marrow transplantation.
Studies on the Chediak-Higashi's disease by the use of an animal model (beige mouse)
  • Thesis to Akita University,
  • 1982
...
1
2
...