The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

@article{Furchgott1980TheOR,
  title={The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine},
  author={Robert F. Furchgott and John V. Zawadzki},
  journal={Nature},
  year={1980},
  volume={288},
  pages={373-376}
}
Despite its very potent vasodilating action in vivo, acetylcholine (ACh) does not always produce relaxation of isolated preparations of blood vessels in vitro. For example, in the helical strip of the rabbit descending thoracic aorta, the only reported response to ACh has been graded contractions, occurring at concentrations above 0.1 µM and mediated by muscarinic receptors1,2. Recently, we observed that in a ring preparation from the rabbit thoracic aorta, ACh produced marked relaxation at… CONTINUE READING
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