The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity.

@article{BertainaAnglade2006TheOR,
  title={The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity.},
  author={Val{\'e}rie Bertaina-Anglade and E Enjuanes and David Morillon and Christophe Drieu La Rochelle},
  journal={Journal of pharmacological and toxicological methods},
  year={2006},
  volume={54 2},
  pages={99-105}
}
INTRODUCTION The aim of the present study was to evaluate the potential usefulness of the object recognition learning paradigm to detect the potential amnesic properties of a new drug for use in the characterisation of its safety pharmacology profile. METHODS AND RESULTS In the first experiment, the time-dependent decay of object recognition memory was characterised in Sprague-Dawley rats and C57Bl/6J mice. Under our experimental conditions, it takes between 3 and 4 post-training hours for… CONTINUE READING