The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain.

@article{Fredriksson2008TheOG,
  title={The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain.},
  author={Robert Fredriksson and Maria H{\"a}gglund and Pawel Karol Olszewski and O. Stephansson and Josefin A. Jacobsson and Agnieszka M Olszewska and Allen Stuart Levine and Jonas Lindblom and Helgi B. Schi{\"o}th},
  journal={Endocrinology},
  year={2008},
  volume={149 5},
  pages={2062-71}
}
Gene variants of the FTO (fatso) gene have recently been strongly associated with body mass index and obesity. The FTO gene is well conserved and found in a single copy in vertebrate species including fish and chicken, suggesting that the ancestor of this gene was present 450 million years ago. Surprisingly, the FTO gene is present in two species of algae but not in any other invertebrate species. This could indicate that this gene has undergone a horizontal gene transfer. Quantitative real… CONTINUE READING
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