The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism.

@article{Rcken2005TheNO,
  title={The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism.},
  author={Christoph R{\"o}cken and Uwe Lendeckel and Jutta Dierkes and Sabine Westphal and Stacy Carl-McGrath and Brigitte Peters and Sabine Krueger and P Malfertheiner and Albert Roessner and Matthias P. A. Ebert},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 7},
  pages={2526-30}
}
PURPOSE In the present study, we aimed to substantiate the putative significance of angiotensin I-converting enzyme (ACE) on gastric cancer biology by investigating the influence of its gene polymorphism on gastric cancer progression. EXPERIMENTAL DESIGN Genomic DNA was purified from peripheral blood mononuclear cells or tissue specimens. Amplified ACE gene fragments were separated on agarose gels. D or I alleles were identified by the presence of 190- or 490-bp fragments, respectively. Local… CONTINUE READING

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