The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age.

@article{Gregg2005TheNO,
  title={The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age.},
  author={Richard A. Gregg and Constance M. Smith and Fiona J. Clark and Debbie Dunnion and Naghma Khan and Ronjon K Chakraverty and Lalitha Nayak and Paul A. H. Moss},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={140 3},
  pages={
          540-6
        }
}
Ageing is associated with evidence of immune deficiency and dysregulation. Key changes in the immune system with ageing include a progressive reduction in naive T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. These features are associated with evidence of impaired immune responsiveness both in vitro and in vivo, termed immune senescence. CD4+ CD25+ T cells have recently been recognized as mediators of peripheral immune regulation and play… CONTINUE READING
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