The number of granule cells in rat hippocampus is reduced after chronic mild stress and re-established after chronic escitalopram treatment.

@article{Jayatissa2008TheNO,
  title={The number of granule cells in rat hippocampus is reduced after chronic mild stress and re-established after chronic escitalopram treatment.},
  author={Magdalena Niepsuj Jayatissa and Christina F. Bisgaard and M. J. West and Ove Wiborg},
  journal={Neuropharmacology},
  year={2008},
  volume={54 3},
  pages={530-41}
}
Stress and depression cause structural changes in the hippocampal formation. Some of these can be reversed by chronic antidepressant treatment. In the present study, we examined the changes in the total number of granule cells and the volume of the granule cell layer after exposing rats to chronic mild stress and chronic escitalopram treatment. Furthermore, we investigated which classes of immature granule cells are affected by stress and targeted by escitalopram. Rats were initially exposed to… CONTINUE READING

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