The number of cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women’s healthy brains

@article{Leuthold2013TheNO,
  title={The number of cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women’s healthy brains},
  author={Arthur C. Leuthold and Margaret Y. Mahan and John J. Stanwyck and Angeliki Georgopoulos and Apostolos P. Georgopoulos},
  journal={Experimental Brain Research},
  year={2013},
  volume={226},
  pages={525-536}
}
Apolipoprotein E (apoE) is involved in lipid metabolism in the brain, but its effects on brain function are not understood. Three apoE isoforms (E4, E3, and E2) are the result of cysteine–arginine interchanges at two sites: there are zero interchanges in E4, one interchange in E3, and two interchanges in E2. The resulting six apoE genotypes (E4/4, E4/3, E4/2, E3/3, E3/2, E2/2) yield five groups with respect to the number of cysteine residues per mole (CysR/mole), as follows. ApoE4/4 has zero… CONTINUE READING

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