The number of CAG repeats within the normal allele does not influence the age of onset in Huntington's disease.

Abstract

Huntington's disease (HD) is caused by the expansion of the number of CAG repeats on the chromosome 4p16.3, which results in elongated glutamine tract of huntingtin. The purpose of this work was to examine the interaction between the normal and mutant alleles of this gene and their effect on the clinical onset of HD. We hypothesized that in patients with… (More)
DOI: 10.1002/mds.23436

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