The null hypothesis of GSEA, and a novel statistical model for competitive gene set analysis

  title={The null hypothesis of GSEA, and a novel statistical model for competitive gene set analysis},
  author={Birgit Debrabant},
Motivation: Competitive gene set analysis intends to assess whether a specific set of genes is more associated with a trait than the remaining genes. However, the statistical models assumed to date to underly these methods do not enable a clear cut formulation of the competitive null hypothesis. This is a major handicap to the interpretation of results obtained from a gene set analysis. Results: This work presents a hierarchical statistical model based on the notion of dependence measures… 

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