The nucleus: a target site for parathyroid hormone-related peptide (PTHrP) action.

@article{Nguyen1998TheNA,
  title={The nucleus: a target site for parathyroid hormone-related peptide (PTHrP) action.},
  author={M T Audrey Nguyen and Andrew C Karaplis},
  journal={Journal of cellular biochemistry},
  year={1998},
  volume={70 2},
  pages={193-9}
}
It is becoming increasingly apparent that parathyroid hormone-related peptide (PTHrP) modulates cellular function in a dual mode of action: first, by binding and activating its cognate cell surface G-protein-coupled receptor and, second, by direct intracellular effects following translocation to the nucleus and/or nucleolus of the target cell. Little is presently known about the mechanisms and events that determine the timing and degree of PTHrP nuclear translocation or the role it may serve in… CONTINUE READING