The nucleotide derivatives inosine and inosinic acid inhibit intestinal absorption of mizoribine in rats.

@article{Okada2006TheND,
  title={The nucleotide derivatives inosine and inosinic acid inhibit intestinal absorption of mizoribine in rats.},
  author={Makoto Okada and Kimihiro Suzuki and Masahiro Nakashima and Takashi Nakanishi and Noriyasu Fujioka},
  journal={European journal of pharmacology},
  year={2006},
  volume={531 1-3},
  pages={
          140-4
        }
}
Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluorothymidine, a Novel Antitumor Nucleoside, in Rats
TLDR
TFT is absorbed via rCNT1 in the intestinal lumen in rats, and the involvement of concentrative nucleoside transporters (CNTs) in TFT absorption into rat small intestine is suggested.
Membrane transport mechanisms of mizoribine in the rat intestine and human epithelial LS180 cells.
TLDR
It is suggested that Na(+)-independent nucleoside transporters are largely responsible for absorption of mizoribine in the intestine.
Impact of concentrative nucleoside transporter 1 gene polymorphism on oral bioavailability of mizoribine in stable kidney transplant recipients.
TLDR
The aim of this study was to evaluate the pharmacokinetic disposition of mizoribine based on polymorphism of concentrative nucleoside transporter (CNT) 1 gene in kidney transplant recipients and to determine whether CNT1 G565A would contribute to interindividual differences in plasma disposition.
Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics
TLDR
Therapeutic drug monitoring of both mizoribine and MTX is expected to improve their clinical efficacy in the treatment of rheumatoid arthritis.
Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency–induced autoimmunity via adenosine A2A receptors
TLDR
It is demonstrated that Foxp3+ T reg cell deficiency results in gut microbial dysbiosis and autoimmunity over the lifespan of scurfy (SF) mouse, and the results reveal that the microbiota–inosine–A2A receptor axis might represent a potential avenue for combatting autoimmune diseases mediated by Treg cell dysfunction.
Population pharmacokinetics of higher-dose mizoribine in healthy male volunteers.
TLDR
The findings indicated that the pharmacokinetics of mizoribine is well described by a simple one-compartment model with first-order absorption.
Population pharmacokinetics of mizoribine in pediatric patients with kidney disease
TLDR
The pharmacokinetics of MZR was different in children compared to adults, and the regular MzR dosage schedule (2–3 mg/kg/day) might be insufficient for pediatric patients, in particular, younger patients might require a higher dosage of Mizoribine per unit body weight.
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References

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TLDR
Results suggest that, in contrast to the human kidney that expresses the N4 nucleoside transporter, the human jejunum expresses both N1 and N2 Na(+)-nucleoside transporters.
Effects of ribavirin on respiratory syncytial virus in vitro
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The antiviral effect was observed to be inversely related to the size of the viral inoculum, although all concentrations above 3.2 micrograms of ribavirin per ml visibly lessened the cytopathic effect regardless of the inoculum.
STUDIES ON BREDININ. I
TLDR
Slight prolongation in the survival period of mice inoculated with lymphatic leukemia L1210 was observed by intraperitoneal injection of bredinin, however, it was not effective on P388 leukemia or EHRLICH ascites tumor.
Pharmacokinetic study of mizoribine in an adolescent with lupus nephritis
TLDR
To the authors' knowledge, there are no reports about monitoring the serum concentration of mizoribine in a pediatric case of lupus nephritis, and the patient was given two different total daily dosages of mIZORibine.
IMMUNOSUPPRESSIVE EFFECT OF BREDININ ON CELL‐MEDIATED AND HUMORAL IMMUNE REACTIONS IN EXPERIMENTAL ANIMALS
TLDR
In beagles, in vitro responses of lymphocytes stimulated by mitogens or allogeneic cells were suppressed by in vitro BR treatment, and BR was found to have an immunosuppressive potency comparable to that of azathioprine and to show a decreased hepatotoxicity compared with the latter.
Dual inhibitory effect of bredinin
TLDR
Bredinin inhibition of cell growth was investigated in the mouse lymphoma cell line L5178Y and it is probably due to bredinin 5′‐phosphate, which inhibits the consecutive enzyme reactions IMP dehydrogenase and GMP synthetase.
A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey)
TLDR
The present study suggested the possibility that long-term MZ therapy may afford further reduction of the UP, in addition to that obtained following CT, in particular, in MN patients in a severe nephrotic state.
Cyclosporine monitoring in patients with renal transplants: two- or three-point methods that estimate area under the curve are superior to trough levels in predicting drug exposure.
TLDR
A two- or three-point method may provide a clinically important improvement over the use of trough levels in monitoring cyclosporine therapy in patients with renal transplants.
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