The nucleoskeleton and the topology of transcription.

@article{Cook1989TheNA,
  title={The nucleoskeleton and the topology of transcription.},
  author={Peter R. Cook},
  journal={European journal of biochemistry},
  year={1989},
  volume={185 3},
  pages={487-501}
}
Transcription is conventionally believed to occur by passage of a mobile polymerase along a fixed template. Evidence for this model is derived almost entirely from material prepared using hypotonic salt concentrations. Studies on subnuclear structures isolated using hypertonic conditions, and more recently using conditions closer to the physiological, suggest an alternative. Transcription occurs as the template moves past a polymerase attached to a nucleoskeleton; this skeleton is the active… CONTINUE READING

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