The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast.

@article{Jin2007TheNN,
  title={The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast.},
  author={Quan-Wen Jin and Samriddha Ray and Sung Hugh Choi and Dannel McCollum},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 8},
  pages={
          2924-34
        }
}
The septation initiation network (SIN) and mitotic exit network (MEN) signaling pathways regulate cytokinesis and mitotic exit in the yeasts Schizosaccharomyces pombe, and Saccharomyces cerevisiae, respectively. One function of these pathways is to keep the Cdc14-family phosphatase, called Clp1 in S. pombe, from being sequestered and inhibited in the nucleolus. In S. pombe, the SIN and Clp1 act as part of a cytokinesis checkpoint that allows cells to cope with cytokinesis defects. The SIN… CONTINUE READING
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