The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen.

@article{Milich1986TheNO,
  title={The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen.},
  author={David R. Milich and Alan McLachlan},
  journal={Science},
  year={1986},
  volume={234 4782},
  pages={1398-401}
}
One characteristic of the immune response during hepatitis B virus (HBV) infection in humans is the vigorous production and subsequent persistence of antibodies of immunoglobulin (Ig) classes M and G to the nucleocapsid antigen (HBcAg). In this study HBcAg was shown to be similarly immunogenic in mice. When injected into athymic (nude) B10.BR and athymic… CONTINUE READING