The nuclease a-inhibitor complex is characterized by a novel metal ion bridge.

@article{Ghosh2007TheNA,
  title={The nuclease a-inhibitor complex is characterized by a novel metal ion bridge.},
  author={Mahua Ghosh and Gregor Meiss and Alfred Pingoud and Robert E. London and Lars C Pedersen},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 8},
  pages={5682-90}
}
Nonspecific, extracellular nucleases have received enhanced attention recently as a consequence of the critical role that these enzymes can play in infectivity by overcoming the host neutrophil defense system. The activity of the cyanobacterial nuclease NucA, a member of the betabetaalpha Me superfamily, is controlled by the specific nuclease inhibitor, NuiA. Here we report the 2.3-A resolution crystal structure of the NucA-NuiA complex, showing that NucA inhibition by NuiA involves an unusual… CONTINUE READING
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…