The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

@article{Verme2005TheNR,
  title={The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.},
  author={Jesse Lo Verme and J. D. Fu and Giuseppe Astarita and Giovanna La Rana and Roberto Russo and Antonio Calignano and Daniele Piomelli},
  journal={Molecular pharmacology},
  year={2005},
  volume={67 1},
  pages={
          15-9
        }
}
Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and ethanolamine, reduces pain and inflammation through an as-yet-uncharacterized mechanism. Here, we identify the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR-alpha) as the molecular target responsible for the anti-inflammatory properties of PEA. PEA selectively activates PPAR-alpha in vitro with an EC(50) value of 3.1 +/- 0.4 microM and induces the expression of PPAR-alpha mRNA when applied… CONTINUE READING

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