The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.

@article{Zhu2014TheNR,
  title={The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.},
  author={Bokai Zhu and Christina H. Ferry and Lauren K. Markell and Nicholas Blazanin and Adam B. Glick and Frank J. Gonzalez and Jeffrey M. Peters},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 29},
  pages={20102-19}
}
Endoplasmic reticulum (ER) stress and ER stress-associated unfolded protein response (UPR) can promote cancer cell survival, but it remains unclear whether they can influence oncogene-induced senescence. The present study examined the role of ER stress in senescence using oncogene-dependent models. Increased ER stress attenuated senescence in part by up-regulating phosphorylated protein kinase B (p-AKT) and decreasing phosphorylated extracellular signal-regulated kinase (p-ERK). A positive feed… CONTINUE READING

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