The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.

@article{Lausen2004TheNR,
  title={The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.},
  author={J{\"o}rn Lausen and Seongeun Cho and Shaohua Liu and Milton H. Werner},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 47},
  pages={49281-8}
}
The acute human leukemias are associated with the presence of chimeric gene products that arise from spontaneous chromosomal translocations. The t(8;21) translocation gene product led to the discovery of the Eight Twenty-One (ETO) gene. When fused to RUNX1, ETO is thought to mediate the formation of a repressive complex at RUNX1-dependent genes. ETO has also been found to act as a co-repressor of the promyelocytic zinc finger and Bcl-6 oncoproteins, suggesting that it may play a common role as… CONTINUE READING
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