The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism.

@article{Delezie2012TheNR,
  title={The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism.},
  author={Julien Delezie and S. Dumont and H. Dardente and H. Oudart and A. Gr{\'e}chez-Cassiau and P. Klosen and M. Teboul and F. Delaunay and P. Pevet and E. Challet},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 8},
  pages={
          3321-35
        }
}
  • Julien Delezie, S. Dumont, +7 authors E. Challet
  • Published 2012
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • Mutations of clock genes can lead to diabetes and obesity. REV-ERBα, a nuclear receptor involved in the circadian clockwork, has been shown to control lipid metabolism. To gain insight into the role of REV-ERBα in energy homeostasis in vivo, we explored daily metabolism of carbohydrates and lipids in chow-fed, unfed, or high-fat-fed Rev-erbα(-/-) mice and their wild-type littermates. Chow-fed Rev-erbα(-/-) mice displayed increased adiposity (2.5-fold) and mild hyperglycemia (∼10%) without… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 68 REFERENCES

    Metabolism and circadian rhythms--implications for obesity.

    • Oren Froy
    • Medicine, Biology
    • Endocrine reviews
    • 2010
    VIEW 2 EXCERPTS

    Bifunctional Role of Rev-erbα in Adipocyte Differentiation

    VIEW 1 EXCERPT

    High-fat feeding alters the clock synchronization to light.

    VIEW 1 EXCERPT