The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism

@article{Delezie2012TheNR,
  title={The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism},
  author={Julien Delezie and S. Dumont and H. Dardente and H. Oudart and A. Gr{\'e}chez-Cassiau and P. Klosen and M. Teboul and F. Delaunay and P. Pevet and E. Challet},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={3321 - 3335}
}
Mutations of clock genes can lead to diabetes and obesity. REV‐ERBα, a nuclear receptor involved in the circadian clockwork, has been shown to control lipid metabolism. To gain insight into the role of REV‐ERBα in energy homeostasis in vivo, we explored daily metabolism of carbohydrates and lipids in chow‐fed, unfed, or high‐fat‐fed Rev‐erbα−/− mice and their wild‐type littermates. Chow‐fed Rev‐erbα−/− mice displayed increased adiposity (2.5‐fold) and mild hyperglycemia (∼10%) without insulin… Expand
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