The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism

@article{Delezie2012TheNR,
  title={The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism},
  author={Julien Delezie and S. Dumont and H. Dardente and H. Oudart and A. Gr{\'e}chez-Cassiau and P. Klosen and M. Teboul and F. Delaunay and P. Pevet and E. Challet},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={3321 - 3335}
}
Mutations of clock genes can lead to diabetes and obesity. REV‐ERBα, a nuclear receptor involved in the circadian clockwork, has been shown to control lipid metabolism. To gain insight into the role of REV‐ERBα in energy homeostasis in vivo, we explored daily metabolism of carbohydrates and lipids in chow‐fed, unfed, or high‐fat‐fed Rev‐erbα−/− mice and their wild‐type littermates. Chow‐fed Rev‐erbα−/− mice displayed increased adiposity (2.5‐fold) and mild hyperglycemia (∼10%) without insulin… Expand
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157 Citations

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Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice
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Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice
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The nuclear retinoid-related orphan receptor-α regulates adipose tissue glyceroneogenesis in addition to hepatic gluconeogenesis.
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Central administration of REV‐ERBα agonist promotes opposite responses on energy balance in fasted and fed states
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The hepatic circadian clock regulates the choline kinase α gene through the BMAL1-REV-ERBα axis
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Nuclear receptor Rev-erbα: up, down, and all around
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