The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism

@article{Delezie2012TheNR,
  title={The nuclear receptor REV‐ERB$\alpha$ is required for the daily balance of carbohydrate and lipid metabolism},
  author={Julien Delezie and St{\'e}phanie Dumont and Hugues Dardente and Hugues Oudart and Aline Gréchez-Cassiau and Paul Klosen and Mich{\`e}le Teboul and Franck Delaunay and Paul P{\'e}vet and Etienne Challet},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={3321 - 3335}
}
Mutations of clock genes can lead to diabetes and obesity. REV‐ERBα, a nuclear receptor involved in the circadian clockwork, has been shown to control lipid metabolism. To gain insight into the role of REV‐ERBα in energy homeostasis in vivo, we explored daily metabolism of carbohydrates and lipids in chow‐fed, unfed, or high‐fat‐fed Rev‐erbα−/− mice and their wild‐type littermates. Chow‐fed Rev‐erbα−/− mice displayed increased adiposity (2.5‐fold) and mild hyperglycemia (∼10%) without insulin… 
Expression of the clock gene Rev‐erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism
TLDR
It is highlighted that Rev‐erbα in the brain is involved in the temporal partitioning of feeding and sleep, whereas its effects on energy metabolism are mainly exerted through its peripheral expression.
Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice
TLDR
It is shown that, unlike knockout mice, Nr1d1 heterozygous mice are not susceptible to muscular atrophy and in fact paradoxically possess larger myofiber diameters and improved neuromuscular function, compared to wildtype mice.
Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice
TLDR
It is shown that, unlike knockout mice, Nr1d1 heterozygous mice are not susceptible to muscular atrophy and in fact paradoxically possess larger myofiber diameters and improved neuromuscular function, compared to wildtype mice.
The nuclear retinoid-related orphan receptor-α regulates adipose tissue glyceroneogenesis in addition to hepatic gluconeogenesis.
TLDR
Results indicated that both adipocyte glyceroneogenesis and hepatocyte gluconeogenesis were regulated by RORα, demonstrating the physiological function of ROR α in regulating both glucose and FFA homeostasis.
Central administration of REV‐ERBα agonist promotes opposite responses on energy balance in fasted and fed states
TLDR
In fasted rats, the agonist promoted increased food intake and feed efficiency, with a greater body weight gain associated with less time spent in locomotor activity, suggesting a reduction in energy expenditure induced by physical activity.
Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice.
TLDR
It is reported that, contrary to females, male mice lacking circadian nuclear receptors REV-ERB alpha and beta in the tuberal hypothalamus (HDKO) gained excessive weight on an obesogenic high fat diet due to both decreased energy expenditure and increased food intake during the light phase.
Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial biogenesis in skeletal muscle
TLDR
Data implicate REV-ERBβ in the control of skeletal muscle metabolism and energy expenditure and suggest that development of REV -ERBα versus REv- ERBβ selective ligands may have therapeutic utility in the treatment of metabolic syndrome.
The hepatic circadian clock regulates the choline kinase α gene through the BMAL1-REV-ERBα axis
TLDR
It is shown that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbα-Chkα axis and suggested that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism.
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References

SHOWING 1-10 OF 72 REFERENCES
Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha.
TLDR
A role for Rev-erbalpha is identified in the regulatory loop of bile acid synthesis, likely acting by regulating both hepatic SHP and E4BP4 expression.
The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet.
TLDR
High-fat diet treatment disrupted the circadian Rev-erbα gene expression profile along with insulin secretion, indicating an important role of this clock gene in β-cell function.
High‐fat feeding alters the clock synchronization to light
TLDR
It is demonstrated that high‐fat feeding modifies circadian synchronization to light using wheel‐running activity and body temperature rhythms as daily phase markers and photic induction of c‐FOS and P‐ERK in the suprachiasmatic nuclei was markedly reduced.
Bifunctional Role of Rev-erbα in Adipocyte Differentiation
TLDR
A dissociation between Rev-erbα mRNA and protein levels that profoundly influences adipocyte differentiation is demonstrated, opposite to what might be predicted fromRev-erb α gene expression, which must rise and then fall for adipocytes differentiation to occur.
Metabolism and circadian rhythms--implications for obesity.
  • O. Froy
  • Biology
    Endocrine reviews
  • 2010
TLDR
This review will focus on the interconnection between the circadian Clock and metabolism, with implications for obesity and how the circadian clock is influenced by hormones, nutrients, and timed meals.
Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes
TLDR
A role for the β-cell clock is demonstrated in coordinating insulin secretion with the sleep–wake cycle, and ablation of the pancreatic clock can trigger the onset of diabetes mellitus.
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
TLDR
It is shown that heme binds reversibly to the orphan nuclear receptor Rev-erbα, a critical negative component of the circadian core clock, and regulates its interaction with a nuclear receptor corepressor complex, serving as a heme sensor that coordinates the cellular clock, glucose homeostasis, and energy metabolism.
Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.
TLDR
Rev-erbalpha modulates the synthesis of its own ligand in a negative feedback pathway that maintains heme levels and regulates cellular energy metabolism.
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ
TLDR
Results from experiments of heme depletion in mammalian cells indicate that heme binding to REV-ERB causes the recruitment of the co-repressor NCoR, leading to repression of target genes including BMAL1, an essential component of the circadian oscillator.
Characterization of peripheral circadian clocks in adipose tissues.
TLDR
It is demonstrated that temporally restricted feeding causes a coordinated phase-shift in circadian expression of the major oscillator genes and their downstream targets in adipose tissues.
...
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