The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism

@article{Delezie2012TheNR,
  title={The nuclear receptor REV‐ERB$\alpha$ is required for the daily balance of carbohydrate and lipid metabolism},
  author={Julien Delezie and St{\'e}phanie Dumont and Hugues Dardente and Hugues Oudart and Aline Gréchez-Cassiau and Paul Klosen and Mich{\`e}le Teboul and Franck Delaunay and Paul P{\'e}vet and Etienne Challet},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={3321 - 3335}
}
Mutations of clock genes can lead to diabetes and obesity. REV‐ERBα, a nuclear receptor involved in the circadian clockwork, has been shown to control lipid metabolism. To gain insight into the role of REV‐ERBα in energy homeostasis in vivo, we explored daily metabolism of carbohydrates and lipids in chow‐fed, unfed, or high‐fat‐fed Rev‐erbα−/− mice and their wild‐type littermates. Chow‐fed Rev‐erbα−/− mice displayed increased adiposity (2.5‐fold) and mild hyperglycemia (∼10%) without insulin… 
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174 Citations

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Expression of the clock gene Rev‐erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism
TLDR
It is highlighted that Rev‐erbα in the brain is involved in the temporal partitioning of feeding and sleep, whereas its effects on energy metabolism are mainly exerted through its peripheral expression.
Rev‐erb regulation of cholesterologenesis
Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice
TLDR
It is shown that, unlike knockout mice, Nr1d1 heterozygous mice are not susceptible to muscular atrophy and in fact paradoxically possess larger myofiber diameters and improved neuromuscular function, compared to wildtype mice.
Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice
TLDR
It is shown that, unlike knockout mice, Nr1d1 heterozygous mice are not susceptible to muscular atrophy and in fact paradoxically possess larger myofiber diameters and improved neuromuscular function, compared to wildtype mice.
The nuclear retinoid-related orphan receptor-α regulates adipose tissue glyceroneogenesis in addition to hepatic gluconeogenesis.
TLDR
Results indicated that both adipocyte glyceroneogenesis and hepatocyte gluconeogenesis were regulated by RORα, demonstrating the physiological function of ROR α in regulating both glucose and FFA homeostasis.
Central administration of REV‐ERBα agonist promotes opposite responses on energy balance in fasted and fed states
TLDR
In fasted rats, the agonist promoted increased food intake and feed efficiency, with a greater body weight gain associated with less time spent in locomotor activity, suggesting a reduction in energy expenditure induced by physical activity.
Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice.
TLDR
It is reported that, contrary to females, male mice lacking circadian nuclear receptors REV-ERB alpha and beta in the tuberal hypothalamus (HDKO) gained excessive weight on an obesogenic high fat diet due to both decreased energy expenditure and increased food intake during the light phase.
Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial biogenesis in skeletal muscle
TLDR
Data implicate REV-ERBβ in the control of skeletal muscle metabolism and energy expenditure and suggest that development of REV -ERBα versus REv- ERBβ selective ligands may have therapeutic utility in the treatment of metabolic syndrome.
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
The hepatic circadian clock regulates the choline kinase α gene through the BMAL1-REV-ERBα axis
TLDR
It is shown that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbα-Chkα axis and suggested that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism.
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