The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism
@article{Delezie2012TheNR, title={The nuclear receptor REV‐ERB$\alpha$ is required for the daily balance of carbohydrate and lipid metabolism}, author={Julien Delezie and St{\'e}phanie Dumont and Hugues Dardente and Hugues Oudart and Aline Gréchez-Cassiau and Paul Klosen and Mich{\`e}le Teboul and Franck Delaunay and Paul P{\'e}vet and Etienne Challet}, journal={The FASEB Journal}, year={2012}, volume={26}, pages={3321 - 3335} }
Mutations of clock genes can lead to diabetes and obesity. REV‐ERBα, a nuclear receptor involved in the circadian clockwork, has been shown to control lipid metabolism. To gain insight into the role of REV‐ERBα in energy homeostasis in vivo, we explored daily metabolism of carbohydrates and lipids in chow‐fed, unfed, or high‐fat‐fed Rev‐erbα−/− mice and their wild‐type littermates. Chow‐fed Rev‐erbα−/− mice displayed increased adiposity (2.5‐fold) and mild hyperglycemia (∼10%) without insulin…
174 Citations
Expression of the clock gene Rev‐erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism
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It is reported that, contrary to females, male mice lacking circadian nuclear receptors REV-ERB alpha and beta in the tuberal hypothalamus (HDKO) gained excessive weight on an obesogenic high fat diet due to both decreased energy expenditure and increased food intake during the light phase.
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Data implicate REV-ERBβ in the control of skeletal muscle metabolism and energy expenditure and suggest that development of REV -ERBα versus REv- ERBβ selective ligands may have therapeutic utility in the treatment of metabolic syndrome.
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The hepatic circadian clock regulates the choline kinase α gene through the BMAL1-REV-ERBα axis
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