The nuclear pregnane X receptor regulates xenobiotic detoxification.

  title={The nuclear pregnane X receptor regulates xenobiotic detoxification.},
  author={Steven A. Kliewer},
  journal={The Journal of nutrition},
  volume={133 7 Suppl},
The pregnane X receptor (PXR), which is a member of the nuclear receptor family of ligand-activated transcription factors, is an integral component of the body's defense mechanism against toxic xenobiotics. PXR is activated by a broad spectrum of lipophilic xenobiotics including prescription drugs, herbs, pesticides, endocrine disruptors and other environmental contaminants. The promiscuous ligand-binding properties of PXR are facilitated by the large volume and smooth shape of its ligand… CONTINUE READING


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