• Corpus ID: 219573779

The nuclear pore complex as an entropic gate: theory and simulation

  title={The nuclear pore complex as an entropic gate: theory and simulation},
  author={Mike Castellano and Steffen Wolf and Thorsten Koslowski},
  journal={arXiv: Biological Physics},
Protein chains of the (FG)$_n$ ($n \simeq$ 300) type cap the cytoplasmatic side of the nucleopore complex, which connects the nucleus to the remainder of an eukaryotic cell. We study the properties of three fundamental polymer models that represent these filaments using Monte Carlo computer simulations. Random walks and the worm like chain model cannot account for the unusual size selectivity of the pore, while a two-dimensional arrangement of intrinsically disordered block copolymers with a… 

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