The nuclear location signal.

@article{Smith1985TheNL,
  title={The nuclear location signal.},
  author={Alan E. Smith and Daniel Kalderon and Barry L. Roberts and William Henry Colledge and Michael D. Edge and Peter Gillett and Anthony Markham and Eva Paucha and William D. L. Richardson},
  journal={Proceedings of the Royal Society of London. Series B, Biological sciences},
  year={1985},
  volume={226 1242},
  pages={
          43-58
        }
}
A short sequence of predominantly basic amino acids Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val from SV40 Large T is responsible for the normal nuclear location of the protein. Alteration of Lys-128 to each of six different residues other than Arg renders Large T cytoplasmic, whereas single amino acid changes in the surrounding region impair but do not prevent nuclear accumulation. When transposed to the amino terminus of cytoplasmic Large T species, or Escherichia coli beta-galactosidase or of chicken… CONTINUE READING

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