The nuclear lamina and heterochromatin: a complex relationship.

@article{Bank2011TheNL,
  title={The nuclear lamina and heterochromatin: a complex relationship.},
  author={Erin M. Bank and Yosef Gruenbaum},
  journal={Biochemical Society transactions},
  year={2011},
  volume={39 6},
  pages={
          1705-9
        }
}
In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact directly with heterochromatin, which implicates the nuclear lamina in a mechanism of specific gene retention at the nuclear periphery and release to the nuclear interior upon gene activation. We also discuss recent data showing that… 
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