The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

@article{Berghe1999TheNF,
  title={The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.},
  author={Wim Vanden Berghe and Karolien De Bosscher and Elke Boone and St{\'e}phane Plaisance and Guy Haegeman},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 45},
  pages={
          32091-8
        }
}
Expression of the pleiotropic cytokine interleukin (IL)-6 can be stimulated by the proinflammatory cytokine tumor necrosis factor (TNF) and the microbial alkaloid staurosporine (STS). In this report, the transcriptional mechanisms were thoroughly investigated. Whereas transcription factors binding to the activator protein-1-, cAMP-responsive element-, and CAAT enhancer-binding protein-responsive sequences are necessary for gene activation by STS, nuclear factor (NF)-kappaB alone is responsible… CONTINUE READING
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