The nuclear exosome contributes to autogenous control of NAB2 mRNA levels.

@article{Roth2005TheNE,
  title={The nuclear exosome contributes to autogenous control of NAB2 mRNA levels.},
  author={Kelly M. Roth and Maria K. Wolf and Marie Louise Rossi and James Scott Butler},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 5},
  pages={
          1577-85
        }
}
The RNA-processing exosome is a complex of riboexonucleases required for 3'-end formation of some noncoding RNAs and for the degradation of mRNAs in eukaryotes. The nuclear form of the exosome functions in an mRNA surveillance pathway that retains and degrades improperly processed precursor mRNAs within the nucleus. We report here that the nuclear exosome controls the level of NAB2 mRNA, encoding the nuclear poly(A)+-RNA-binding protein Nab2p. Mutations affecting the activity of the nuclear… CONTINUE READING
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