Corpus ID: 36325702

The nuclear epidermal growth factor receptor signaling network and its role in cancer.

  title={The nuclear epidermal growth factor receptor signaling network and its role in cancer.},
  author={T. Brand and M. Iida and C. Li and D. L. Wheeler},
  journal={Discovery medicine},
  volume={12 66},
  • T. Brand, M. Iida, +1 author D. L. Wheeler
  • Published 2011
  • Biology, Medicine
  • Discovery medicine
  • The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through various pathways ultimately resulting in cellular proliferation, survival, angiogenesis, invasion, and metastasis. Aberrant expression or activity of EGFR has been strongly linked to the etiology of several human epithelial cancers including but not limited to head and neck squamous cell carcinoma (HNSCC), non-small cell… CONTINUE READING
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