The nuclear coactivator Amplified In Breast Cancer 1 maintains tumor initiating cells during development of Ductal Carcinoma In Situ

@inproceedings{Ory2014TheNC,
  title={The nuclear coactivator Amplified In Breast Cancer 1 maintains tumor initiating cells during development of Ductal Carcinoma In Situ},
  author={Virginie Ory and Elena Tassi and LR Cavalli and GM Sharif and Fransisco Saenz and T. L. Baker and M O Schmidt and S. Mueller and Pa Furth and Anton Wellstein and At Riegel},
  booktitle={Oncogene},
  year={2014}
}
The key molecular events required for the formation of ductal carcinoma in situ (DCIS) and its progression to invasive breast carcinoma have not been defined. Here, we show that the nuclear receptor coactivator amplified in breast cancer 1 (AIB1) is expressed at low levels in normal breast but is highly expressed in DCIS lesions. This is of significance since reduction of AIB1 in human MCFDCIS cells restored a more normal three-dimensional mammary acinar structure. Reduction of AIB1 in MCFDCIS… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Cancer stem cells and early stage basal-like breast cancer

  • World journal of obstetrics and gynecology
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012