The nuclear basket mediates perinuclear mRNA scanning in budding yeast

@inproceedings{Saroufim2015TheNB,
  title={The nuclear basket mediates perinuclear mRNA scanning in budding yeast},
  author={Mark-Albert Saroufim and Pierre Bensidoun and Pascal Raymond and Samir Abdel Rahman and Matthew R. Krause and Marlene Oeffinger and Daniel Zenklusen},
  booktitle={The Journal of cell biology},
  year={2015}
}
After synthesis and transit through the nucleus, messenger RNAs (mRNAs) are exported to the cytoplasm through the nuclear pore complex (NPC). At the NPC, messenger ribonucleoproteins (mRNPs) first encounter the nuclear basket where mRNP rearrangements are thought to allow access to the transport channel. Here, we use single mRNA resolution live cell microscopy and subdiffraction particle tracking to follow individual mRNAs on their path toward the cytoplasm. We show that when reaching the… CONTINUE READING

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