The nuclear RNase III Drosha initiates microRNA processing

  title={The nuclear RNase III Drosha initiates microRNA processing},
  author={Yoontae Lee and C. Ahn and J. Han and Hyounjeong Choi and Jaekwang Kim and J. Yim and J. Lee and P. Provost and O. R{\aa}dmark and S. Kim and V. Kim},
  • Yoontae Lee, C. Ahn, +8 authors V. Kim
  • Published 2003
  • Medicine, Biology
  • Nature
  • Hundreds of small RNAs of ∼22 nucleotides, collectively named microRNAs (miRNAs), have been discovered recently in animals and plants. Although their functions are being unravelled, their mechanism of biogenesis remains poorly understood. miRNAs are transcribed as long primary transcripts (pri-miRNAs) whose maturation occurs through sequential processing events: the nuclear processing of the pri-miRNAs into stem-loop precursors of ∼70 nucleotides (pre-miRNAs), and the cytoplasmic processing of… CONTINUE READING
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