The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.

@article{Hirotani2005TheNI,
  title={The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.},
  author={Tomonori Hirotani and Pui Y Lee and Hirotaka Kuwata and Masahiro Yamamoto and Makoto Matsumoto and Ichiro Kawase and Shizuo Akira and Kiyoshi Takeda},
  journal={Journal of immunology},
  year={2005},
  volume={174 6},
  pages={3650-7}
}
Macrophages play an important role in the pathogenesis of chronic colitis. However, it remains unknown how macrophages residing in the colonic lamina propria are regulated. We characterized colonic lamina proprial CD11b-positive cells (CLPMphi). CLPMphi of wild-type mice, but not IL-10-deficient mice, displayed hyporesponsiveness to TLR stimulation in terms of cytokine production and costimulatory molecule expression. We compared CLPMphi gene expression profiles of wild-type mice with IL-10… CONTINUE READING

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