The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription

@article{Cutress2003TheNB,
  title={The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription},
  author={Ramsey I. Cutress and Paul A. Townsend and Adam Sharp and Anna Maison and Lynn Wood and Ron Lee and Matthew Brimmell and Mark A. Mullee and Peter W. M. Johnson and G. Royle and Adrian C Bateman and Graham Packham},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={4973-4982}
}
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L, BAG-1M and BAG-1S. BAG-1L contains a nuclear localization signal, which is not present in the other isoforms, and is predominantly localized in the cell nucleus. Here we have investigated the effects of BAG-1 on function of the oestrogen receptor (ER), a key growth control molecule and target for… CONTINUE READING
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