The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis.

@article{Zhang2015TheNA,
  title={The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis.},
  author={Ronghua Zhang and Kai Wang and Xianqiang Ping and Wenjing Yu and Zhikang Qian and Sidong Xiong and Bing Sun},
  journal={Journal of virology},
  year={2015},
  volume={89 22},
  pages={11383-95}
}
UNLABELLED An accessory gene between the S and E gene loci is contained in all coronaviruses (CoVs), and its function has been studied in some coronaviruses. This gene locus in human coronavirus OC43 (HCoV-OC43) encodes the ns12.9 accessory protein; however, its function during viral infection remains unknown. Here, we engineered a recombinant mutant virus lacking the ns12.9 protein (HCoV-OC43-Δns12.9) to characterize the contributions of ns12.9 in HCoV-OC43 replication. The ns12.9 accessory… CONTINUE READING
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