The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages.

@article{ZieglerHeitbrock1993TheNS,
  title={The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages.},
  author={H W Loms Ziegler-Heitbrock and Gerhard Fingerle and Martin Stroebel and Winfried W Schraut and Felix Stelter and Christine Schuett and Bernward Passlick and Almuth Pforte},
  journal={European journal of immunology},
  year={1993},
  volume={23 9},
  pages={
          2053-8
        }
}
The CD14+/CD16+ cells account for about 10% of all blood monocytes. They are characterized by a low level expression of the CD14 molecule and a high level expression of the CD16 (Fc gamma R III) molecule. Polymerase chain reaction analysis of mRNA prevalence in CD14+/CD16+ cells (compared to the regular CD14++ blood monocytes) demonstrates low levels of CD14 transcripts and high levels of CD16 transcripts, suggestive of a transcriptional control for both of these proteins. Analysis of… CONTINUE READING
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