• Corpus ID: 12268040

The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra.

@article{Grens1999TheNS,
  title={The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra.},
  author={A Grens and Hiroshi Shimizu and S. A. H. Hoffmeister and Hans R. Bode and Toshitaka Fujisawa},
  journal={Development},
  year={1999},
  volume={126 3},
  pages={
          517-24
        }
}
Signaling molecules affecting patterning processes are usually proteins and rarely peptides. Two novel peptides, pedibin and Hym-346, that are closely related to one another have been isolated from Hydra vulgaris and Hydra magnipapillata. Several experiments indicate that both cause a reduction in the positional value gradient, the principle patterning process governing the maintenance of form in the adult hydra. The peptides cause an increase in the rate of foot regeneration following… 

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PII: S0925-4773(01)00401-4
TLDR
The data presented here show that pedibin is synthesized as a precursor of 49 amino acids, a putative cleavage site precedes the peptide as puri®ed from hydra tissue, which accelerates foot regeneration.
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