The novel serine protease PreR-Co promotes endothelium-independent vasorelaxation in rabbit aortic rings.

  title={The novel serine protease PreR-Co promotes endothelium-independent vasorelaxation in rabbit aortic rings.},
  author={Mar{\'i}a de los {\'A}ngeles Peral de Bruno and Paula Andrea Vincent and Liliana Romano and D C Guardia and Alfredo Coviello and Eduardo De Vito},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={284 2},
The effect of a novel enzyme (PreR-Co) that activates renal prorenin was studied on rabbit aortas with and without endothelium. It was tested 1) in the basal tone of nonstimulated or ANG II-sensitized rings or rings precontracted with norepinephrine (NE), PGF(2alpha), high KCl concentration, and 2) in rings pretreated with enalaprilat, losartan, PD-123319, N(omega)-nitro-l-arginine methyl ester, HOE-140, indomethacin, or serine protease inhibitors (PMSF, aprotinin, or soybean trypsin inhibitor… 

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The data suggest that a prostanoidmediated and endothelium-dependent mechanism of vasoconstriction contributes to the constrictor effect of angiotensin II in aortic rings of rats in the early phase of aorti coarctation-induced hypertension.

Losartan reduces the vasorelaxant effect of atrial natriuretic peptide on basal tone in aorta.

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Data support the hypothesis that the EETs are EDHFs, which causes endothelium-dependent relaxations of coronary arteries through its metabolism to epoxyeicosatrienoic acids by cytochrome P450 by boosting the open-state probability of a Ca2+-activated K+ channel in coronary smooth muscle cells.

Angiotensin IV-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release.

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    American journal of physiology. Lung cellular and molecular physiology
  • 2000
Results demonstrate that ANG IV-mediated vasodilation of PAs is endothelium dependent and regulated by [Ca(2+)](i) release through receptor-coupled G protein-phospholipase C-PI 3-kinase signaling mechanisms.

The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels

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Relaxation of non-contracted smooth muscle by atrial natriuretic peptide.

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Effects of kinins on isolated blood vessels. Role of endothelium.

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