The novel serine protease PreR-Co promotes endothelium-independent vasorelaxation in rabbit aortic rings.

@article{PeraldeBruno2003TheNS,
  title={The novel serine protease PreR-Co promotes endothelium-independent vasorelaxation in rabbit aortic rings.},
  author={Mar{\'i}a de los {\'A}ngeles Peral de Bruno and Paula Andrea Vincent and Liliana Romano and D C Guardia and Alfredo Coviello and Eduardo De Vito},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 2},
  pages={
          H704-10
        }
}
The effect of a novel enzyme (PreR-Co) that activates renal prorenin was studied on rabbit aortas with and without endothelium. It was tested 1) in the basal tone of nonstimulated or ANG II-sensitized rings or rings precontracted with norepinephrine (NE), PGF(2alpha), high KCl concentration, and 2) in rings pretreated with enalaprilat, losartan, PD-123319, N(omega)-nitro-l-arginine methyl ester, HOE-140, indomethacin, or serine protease inhibitors (PMSF, aprotinin, or soybean trypsin inhibitor… 
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