• Corpus ID: 89093603

The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg?related proteins in cisplatin?resistant CAR human oral cancer cells

  title={The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg?related proteins in cisplatin?resistant CAR human oral cancer cells},
  author={謝閔凔 and 黃麗嬌 and 郭盛助},

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling.

The findings indicate that resveratrol is likely to induce autophagic and apoptotic death in drug-resistant oral cancer cells and might become a new approach for oral cancer treatment in the near future.

Epigallocatechin gallate sensitizes cisplatin‐resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling

Overall, downregulation of MDR1 levels and alterations of AKT/STAT3 signaling contributed to EGCG‐induced apoptosis and autophagy in CAR cells.

An Efficient Synthesis of Fused Polycyclic Triazolo[4,5-a]acridine Derivatives under Catalyst-Free Conditions with High Regioselectivity

An efficient synthesis of fused polycyclic 11-aryl-7,8,9,11-tetrahydro-1H-[1,2,3] triazolo[4,5-a]acridin-10(6H)-one derivatives is described in EtOH with high regioselectivity. This new procedure

Acetylshikonin induces autophagy‐dependent apoptosis through the key LKB1‐AMPK and PI3K/Akt‐regulated mTOR signalling pathways in HL‐60 cells

The results demonstrate that ASK remarkably inhibited the cell proliferation, viability and induced apoptosis in HL‐60 cells through the mitochondrial pathway, and ASK promoted cell cycle arrest in the S‐phase, and reveal that ASk‐induced HL‐ 60 cell apoptosis is dependent on the activation of autophagy via the LKB1/AMPK and PI3K/Akt/mTOR signalling pathways.

Enhancement of Anticancer Potential of Pterostilbene Derivative by Chalcone Hybridization

A number of pterostilbene derivatives were discovered to possess potent anticancer potentials, and compound 4d was the most active, more active than the parent pterotoxic molecule.

Autophagy—A Hidden but Important Actor on Oral Cancer Scene

Understanding how to overcome cytoprotective autophagy and how to take advantage of autophagic cell death is critical in order to enhance the cancer cells sensitivity to particular therapeutic agents.

Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells.

The findings are the first to suggest that PCE may be potentially efficacious for the treatment of cisplatin‑resistant human oral cancer.

Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells.

The results supported the potential application of ursolic acid against drug‑resistant oral carcinoma and to improve oral anticancer efficacy in the near future.

Pterostilbene modulates the suppression of multidrug resistance protein 1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling

Pterostilbene is a natural polyphenolic compound that is primarily found in fruits, such as blueberries and has a similar structure to resveratrol. Pterostilbene exhibits antioxidant,

Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer

It is proposed that pterostilbene is one ideal alternative medicine to be administered in the diet as a nutritional supplement in order to clinically utilize PS as novel cancer therapeutic remedies.