The novel non-steroidal selective androgen receptor modulator S-101479 has additive effects with bisphosphonate, selective estrogen receptor modulator, and parathyroid hormone on the bones of osteoporotic female rats.

@article{Furuya2012TheNN,
  title={The novel non-steroidal selective androgen receptor modulator S-101479 has additive effects with bisphosphonate, selective estrogen receptor modulator, and parathyroid hormone on the bones of osteoporotic female rats.},
  author={Kazuyuki Furuya and Noriko Yamamoto and Yuki Ohyabu and Akito Makino and Teruyuki Morikyu and Hirohide Ishige and Kazuya Kuzutani and Yasuhisa Endo},
  journal={Biological & pharmaceutical bulletin},
  year={2012},
  volume={35 7},
  pages={1096-104}
}
We have studied non-steroidal selective androgen receptor modulators (SARMs) to develop anti-osteoporosis drugs for males and females. Many SARMs have been studied for their anabolic effects on bone or muscle with reduced virilizing effects in male animals. However, the tissue selectivities of these agents in female animals have not been fully evaluated. We evaluated the novel SARM S-101479 from tetrahydroquinoline libraries in ovariectomized (OVX) rats. S-101479 preferentially bound to the… CONTINUE READING