The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage.

@article{Mechlovich2010TheNM,
  title={The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage.},
  author={Danit Mechlovich and Tamar Amit and Silvia A. Mandel and Orit Bar-Am and Konstantin Bloch and Pnina Vardi and Moussa B. H. Youdim},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={333 3},
  pages={
          874-82
        }
}
Increasing evidence suggests that oxidative stress (OS)-induced pancreatic beta-cell impairments is involved in diabetes and diabetic complications. Our group has recently synthesized two multifunctional nontoxic, lipophilic, iron-chelating drugs, 5-{N-methyl-N-propargylaminomethyl}-8-hydroxyquinoline (M30) and 5-{4-propargylpiperazin-1-ylmethyl}-8-hydroxyquinoline (HLA20), for the treatment of various OS-mediated pathogeneses. These compounds contain the N-propargylamine cytoprotective moiety… CONTINUE READING
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